Device-based fluid system to guide diuretic therapy

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Hemodynamic parameters to guide fluid therapy

The clinical determination of the intravascular volume can be extremely difficult in critically ill and injured patients as well as those undergoing major surgery. This is problematic because fluid loading is considered the first step in the resuscitation of hemodynamically unstable patients. Yet, multiple studies have demonstrated that only approximately 50% of hemodynamically unstable patient...

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[Diuretic-based therapy].

Diuretics are pharmacological agents that increase natriuresis through inhibition of tubular re-absorption of sodium. The mechanisms and site of this inhibition differ with each drug class, accounting for their additive effects on natriuresis increase and their hydroelectrolytic side effects. The response to a given diuretic dose depends on the diuretic concentration on the urine at its action ...

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Hemodynamic Parameters to Guide Fluid Therapy (printer-friendly)

and Introduction Abstract The clinical determination of the intravascular volume can be extremely difficult in critically ill and injured patients as well as those undergoing major surgery. This is problematic as fluid loading is considered the first step in the resuscitation of hemodynamically unstable patients. Yet, multiple studies have demonstrated that only about 50% of hemodynamically uns...

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Model-Based Decision Support Algorithm to Guide Fluid Resuscitation ?

Fluid resuscitation is the first choice therapy for sepctic shock. However, fluid infusion only increases cardiac output in approximately 50 % of cases, while an excess of fluid can have harmful effects. Therefore, clinicians are looking for indices to predict the effect of fluid infusion on cardiac output, before giving fluid. In this work, a minimal mathematical model of the cardiovascular sy...

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Improved persistence and adherence to diuretic fixed-dose combination therapy compared to diuretic monotherapy

BACKGROUND Diuretics are recommended as initial treatment for hypertension. Several studies have suggested suboptimal persistence and adherence to thiazide diuretic monotherapy; this study compared patient persistence and adherence with hydrochlorothiazide (HCTZ) monotherapy to fixed-dose combinations containing HCTZ. METHODS Patients with at least one prescription claim during 2001 to 2003 f...

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ژورنال

عنوان ژورنال: Nature Reviews Cardiology

سال: 2019

ISSN: 1759-5002,1759-5010

DOI: 10.1038/s41569-019-0228-8